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A gene-rich, transcriptionally active environment and the pre-deposition of repressive marks are predictive of susceptibility to KRAB/KAP1-mediated silencing

<p>Abstract</p> <p>Background</p> <p>KRAB-ZFPs (Krüppel-associated box domain-zinc finger proteins) are vertebrate-restricted transcriptional repressors encoded in the hundreds by the mouse and human genomes. They act via an essential cofactor, KAP1, which recruits effectors responsible for the form...

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Principais autores: Zangger Nadine, Quenneville Simon, Malani Nirav, Ambrosini Giovanna, Groner Anna C, Meylan Sylvain, Kapopoulou Adamandia, Kauzlaric Annamaria, Rougemont Jacques, Ciuffi Angela, Bushman Frederic D, Bucher Philipp, Trono Didier
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2011-07-01
coleção:BMC Genomics
Assuntos:
KAP1
KRAB-zinc finger proteins
transcriptional repression
chromatin
heterochromatin
histone modifications
Acesso em linha:http://www.biomedcentral.com/1471-2164/12/378
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