The phage T4 DNA ligase mediates bacterial chromosome DSBs repair as single component non-homologous end joining

DNA double-strand breaks (DSBs) are one of the most lethal forms of DNA damage that is not efficiently repaired in prokaryotes. Certain microorganisms can handle chromosomal DSBs using the error-prone non-homologous end joining (NHEJ) system and ultimately cause genome mutagenesis. Here, we demonstr...

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Bibliografske podrobnosti

Principais autores:	Tianyuan Su, Fapeng Liu, Yizhao Chang, Qi Guo, Junshu Wang, Qian Wang, Qingsheng Qi
Format:	Artigo
Jezik:	Inglês
Izdano:	KeAi Communications Co., Ltd. 2019-06-01
Serija:	Synthetic and Systems Biotechnology
Online dostop:	http://www.sciencedirect.com/science/article/pii/S2405805X19300018
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