In-silico, in-vitro, and proteomics analyses on repurposed drugs in targeting the small GTPase, Rho subfamily protein (Rho GTPase), and putative Rho GTPase-activating protein (RhoGAP) of Giardia lamblia

Giardia lamblia is a globally prevalent protozoan responsible for Giardiasis, an intestinal disease commonly treated with nitroimidazoles such as metronidazole, tinidazole, and albendazole. However, increasing drug resistance has reduced treatment efficacy. Rho GTPase and its regulator, putative Rho...

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Autors principals:	Nurhana Jasni, Khairul Bariyyah Abd. Halim, Wong Weng Kin, Darren Lau, Clifford Young, Peter Hoffmann, Nurulhasanah Othman
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2025-12-01
Col·lecció:	Journal of Genetic Engineering and Biotechnology
Matèries:	Giardia lamblia Rho-GTPase activating protein Rho GTPase Repurposed Drug Proteomics In-silico
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S1687157X25001179
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