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In-silico, in-vitro, and proteomics analyses on repurposed drugs in targeting the small GTPase, Rho subfamily protein (Rho GTPase), and putative Rho GTPase-activating protein (RhoGAP) of Giardia lamblia

Giardia lamblia is a globally prevalent protozoan responsible for Giardiasis, an intestinal disease commonly treated with nitroimidazoles such as metronidazole, tinidazole, and albendazole. However, increasing drug resistance has reduced treatment efficacy. Rho GTPase and its regulator, putative Rho...

Deskribapen osoa

Gorde:
Egile Nagusiak: Nurhana Jasni, Khairul Bariyyah Abd. Halim, Wong Weng Kin, Darren Lau, Clifford Young, Peter Hoffmann, Nurulhasanah Othman
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier 2025-12-01
Saila:Journal of Genetic Engineering and Biotechnology
Gaiak:
Giardia lamblia
Rho-GTPase activating protein
Rho GTPase
Repurposed Drug
Proteomics
In-silico
Sarrera elektronikoa:http://www.sciencedirect.com/science/article/pii/S1687157X25001179
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