Notum deacylates octanoylated ghrelin

Objectives: The only proteins known to be modified by O-linked lipidation are Wnts and ghrelin, and enzymatic removal of this post-translational modification inhibits ligand activity. Indeed, the Wnt-deacylase activity of Notum is the basis of its ability to act as a feedback inhibitor of Wnt signal...

תיאור מלא

מידע ביבליוגרפי

Principais autores:	Yuguang Zhao, Laura-Nadine Schuhmacher, Morgan Roberts, Satoshi Kakugawa, Ganka Bineva-Todd, Steve Howell, Nicola O'Reilly, Christine Perret, Ambrosius P. Snijders, Jean-Paul Vincent, E. Yvonne Jones
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Elsevier 2021-07-01
סדרה:	Molecular Metabolism
נושאים:	Notum Ghrelin Deacylation Crystal structure Metabolism
גישה מקוונת:	http://www.sciencedirect.com/science/article/pii/S2212877821000417
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!