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Notum deacylates octanoylated ghrelin

Objectives: The only proteins known to be modified by O-linked lipidation are Wnts and ghrelin, and enzymatic removal of this post-translational modification inhibits ligand activity. Indeed, the Wnt-deacylase activity of Notum is the basis of its ability to act as a feedback inhibitor of Wnt signal...

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Autori principali: Yuguang Zhao, Laura-Nadine Schuhmacher, Morgan Roberts, Satoshi Kakugawa, Ganka Bineva-Todd, Steve Howell, Nicola O'Reilly, Christine Perret, Ambrosius P. Snijders, Jean-Paul Vincent, E. Yvonne Jones
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2021-07-01
Serie:Molecular Metabolism
Soggetti:
Notum
Ghrelin
Deacylation
Crystal structure
Metabolism
Accesso online:http://www.sciencedirect.com/science/article/pii/S2212877821000417
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