Microneedle-mediated transdermal delivery of siRNA-loaded nanoparticles for atopic dermatitis therapy by disrupting cuproptosis-pyroptosis crosstalk

Abstract Background Atopic dermatitis (AD) is a common chronic inflammatory skin disorder characterized by epidermal barrier dysfunction and immune dysregulation, yet effective long-term therapies are limited. Although regulated cell death has been linked to AD, the involvement of copper-dependent c...

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Váldodahkkit:	Pian Yu, Chi Fang, Zhisheng Luo, Lu Hao, Kaixuan Li, Rongxuan Yan, Sihui Ma, Guanming Wang, Qiaozhi Cao, Jie Dong, Xiang Chen, Jie Li, Peng Liu, Shuo Hu, Cong Peng
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	BMC 2026-05-01
Ráidu:	Journal of Nanobiotechnology
Fáttát:	Atopic dermatitis Calcium phosphate nanoparticles siRNA Transdermal delivery Cuproptosis Pyroptosis
Liŋkkat:	https://doi.org/10.1186/s12951-026-04533-9
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