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Microneedle-mediated transdermal delivery of siRNA-loaded nanoparticles for atopic dermatitis therapy by disrupting cuproptosis-pyroptosis crosstalk

Abstract Background Atopic dermatitis (AD) is a common chronic inflammatory skin disorder characterized by epidermal barrier dysfunction and immune dysregulation, yet effective long-term therapies are limited. Although regulated cell death has been linked to AD, the involvement of copper-dependent c...

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Principais autores: Pian Yu, Chi Fang, Zhisheng Luo, Lu Hao, Kaixuan Li, Rongxuan Yan, Sihui Ma, Guanming Wang, Qiaozhi Cao, Jie Dong, Xiang Chen, Jie Li, Peng Liu, Shuo Hu, Cong Peng
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-05-01
Serier:Journal of Nanobiotechnology
Fag:
Atopic dermatitis
Calcium phosphate nanoparticles
siRNA
Transdermal delivery
Cuproptosis
Pyroptosis
Online adgang:https://doi.org/10.1186/s12951-026-04533-9
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