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Interaction of transcription factor AP‐2 gamma with proto‐oncogene PELP1 promotes tumorigenesis by enhancing RET signaling

A significant proportion of estrogen receptor‐positive (ER+) breast cancer (BC) initially responds to endocrine therapy but eventually evolves into therapy‐resistant BC. Transcription factor AP‐2 gamma (TFAP2C) is a known regulator of ER activity, and high expression of TFAP2C is associated with a d...

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Principais autores: Junhao Liu, Zexuan Liu, Mengxing Li, Weiwei Tang, Uday P. Pratap, Yiliao Luo, Kristin A. Altwegg, Xiaonan Li, Yi Zou, Hong Zhu, Gangadhara R. Sareddy, Suryavathi Viswanadhapalli, Ratna K. Vadlamudi
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2021-04-01
Serier:Molecular Oncology
Fag:
breast cancer
coactivator
PELP1
TFAP2C
therapy resistance
Online adgang:https://doi.org/10.1002/1878-0261.12871
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