PELP1 inhibition by SMIP34 reduces endometrial cancer progression via attenuation of ribosomal biogenesis

Endometrial carcinoma (ECa) is the fourth most common cancer among women. The oncogene PELP1 is frequently overexpressed in a variety of cancers, including ECa. We recently generated SMIP34, a small‐molecule inhibitor of PELP1 that suppresses PELP1 oncogenic signaling. In this study, we assessed the...

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Autors principals:	Xue Yang, Zexuan Liu, Weiwei Tang, Uday P. Pratap, Alexia B. Collier, Kristin A. Altwegg, Rahul Gopalam, Xiaonan Li, Yaxia Yuan, Daohong Zhou, Zhao Lai, Yidong Chen, Gangadhara R. Sareddy, Philip T. Valente, Edward R. Kost, Suryavathi Viswanadhapalli, Ratna K. Vadlamudi
Format:	Artigo
Idioma:	Inglês
Publicat:	Wiley 2024-09-01
Col·lecció:	Molecular Oncology
Matèries:	endometrial cancer mTOR PELP1 rapamycin ribosomal biogenesis
Accés en línia:	https://doi.org/10.1002/1878-0261.13539
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