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Targeting FAP/CAFs to rewire immune-excluded and resistant tumor niches

Immune checkpoint blockade (ICB) has reshaped cancer therapy, yet many solid tumors remain immune-excluded, with cytotoxic T cells trapped in stromal regions and unable to access malignant nests. In these settings, cancer-associated fibroblasts (CAFs) and their extracellular matrix programs act as a...

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Principais autores: Yingying Wang, Yajun Zhao, Ce Zhou, Yang Wang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-06-01
Serier:Frontiers in Pharmacology
Fag:
cancer-associated fibroblasts
checkpoint blockade resistance
FAPI-PET
fibroblast activation protein
immune exclusion
tumor microenvironment
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2026.1812674/full
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