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Microglia Exhibit a Unique Intact HIV Reservoir in Human Postmortem Brain Tissue

A proviral reservoir persists within the central nervous system (CNS) of people with HIV, but its characteristics remain poorly understood. Research has primarily focused on cerebrospinal fluid (CSF), as acquiring brain tissue is challenging. We examined size, cellular tropism, and infection-dynamic...

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Principais autores: Marieke M. Nühn, Stephanie B. H. Gumbs, Pauline J. Schipper, Irene Drosou, Lavina Gharu, Ninée V. E. J. Buchholtz, Gijsje J. L. J. Snijders, Frederieke A. J. Gigase, Annemarie M. J. Wensing, Jori Symons, Lot D. de Witte, Monique Nijhuis
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2025-03-01
coleção:Viruses
Assuntos:
HIV
brain
CNS
replication-competent
cellular tropism
microglia
Acesso em linha:https://www.mdpi.com/1999-4915/17/4/467
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