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Antiretroviral drug therapy does not reduce neuroinflammation in an HIV-1 infection brain organoid model

Abstract Background HIV-1-associated neurocognitive impairment (HIV-1-NCI) is marked by ongoing and chronic neuroinflammation with loss and decline in neuronal function even when antiretroviral drug therapy (ART) successfully suppresses viral replication. Microglia, the primary reservoirs of HIV-1 i...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Samuel Martinez-Meza, Thomas A. Premeaux, Stefano M. Cirigliano, Courtney M. Friday, Stephanie Michael, Sonia Mediouni, Susana T. Valente, Lishomwa C. Ndhlovu, Howard A. Fine, Robert L. Furler O’Brien, Douglas F. Nixon
Hōputu: Artigo
Reo:Inglês
I whakaputaina: BMC 2025-03-01
Rangatū:Journal of Neuroinflammation
Ngā marau:
HIV-1
Neurocognitive
Brain
Organoid
Microglia
Neurons
Urunga tuihono:https://doi.org/10.1186/s12974-025-03375-w
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