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Inflammatory responses revealed through HIV infection of microglia-containing cerebral organoids

Abstract Cerebral organoids (COs) are valuable tools for studying the intricate interplay between glial cells and neurons in brain development and disease, including HIV-associated neuroinflammation. We developed a novel approach to generate microglia containing COs (CO-iMs) by co-culturing hematopo...

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Furkejuvvon:
Váldodahkkit: Srinivas D. Narasipura, Janet P. Zayas, Michelle K. Ash, Anjelica F. Reyes, Tanner Shull, Stephanie Gambut, James L. A. Szczerkowski, Charia McKee, Jeffrey R. Schneider, Ramon Lorenzo-Redondo, Lena Al-Harthi, João I. Mamede
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: BMC 2025-02-01
Ráidu:Journal of Neuroinflammation
Fáttát:
Cerebral organoids
Microglia
HIV
Neuropathogenesis
Neuroinflammation
IPSC
Liŋkkat:https://doi.org/10.1186/s12974-025-03353-2
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