Inflammatory responses revealed through HIV infection of microglia-containing cerebral organoids

Abstract Cerebral organoids (COs) are valuable tools for studying the intricate interplay between glial cells and neurons in brain development and disease, including HIV-associated neuroinflammation. We developed a novel approach to generate microglia containing COs (CO-iMs) by co-culturing hematopo...

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Auteurs principaux:	Srinivas D. Narasipura, Janet P. Zayas, Michelle K. Ash, Anjelica F. Reyes, Tanner Shull, Stephanie Gambut, James L. A. Szczerkowski, Charia McKee, Jeffrey R. Schneider, Ramon Lorenzo-Redondo, Lena Al-Harthi, João I. Mamede
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2025-02-01
Collection:	Journal of Neuroinflammation
Sujets:	Cerebral organoids Microglia HIV Neuropathogenesis Neuroinflammation IPSC
Accès en ligne:	https://doi.org/10.1186/s12974-025-03353-2
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