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Anti-HIV-1 Nanobody-IgG1 Constructs With Improved Neutralization Potency and the Ability to Mediate Fc Effector Functions

The most effective treatment for HIV-1, antiretroviral therapy, suppresses viral replication and averts the disease from progression. Nonetheless, there is a need for alternative treatments as it requires daily administration with the possibility of side effects and occurrence of drug resistance. Br...

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Sábháilte in:
Príomhchruthaitheoirí: Angela I. Schriek, Marlies M. van Haaren, Meliawati Poniman, Gillian Dekkers, Arthur E. H. Bentlage, Marloes Grobben, Gestur Vidarsson, Rogier W. Sanders, Theo Verrips, Teunis B. H. Geijtenbeek, Raimond Heukers, Neeltje A. Kootstra, Steven W. de Taeye, Marit J. van Gils
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Frontiers Media S.A. 2022-05-01
Sraith:Frontiers in Immunology
Ábhair:
HIV-1
nanobodies
neutralization
Fc fusion
Fc-mediated effector functions
Rochtain ar líne:https://www.frontiersin.org/articles/10.3389/fimmu.2022.893648/full
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