IgG subclasses and allotypes: from structure to effector functions

Of the five immunoglobulin isotypes, Immunoglobulin G (IgG) is most abundant in human serum. The four subclasses, IgG1, IgG2, IgG3 and IgG4 which are highly conserved, differ in their constant region, particularly in their hinges and upper CH2 domains. These regions are involved in binding to both I...

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Κύριοι συγγραφείς:	Gestur eVidarsson, Gillian eDekkers, Theo eRispens
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Frontiers Media S.A. 2014-10-01
Σειρά:	Frontiers in Immunology
Θέματα:	Glycosylation Immunoglobulin G Polymorphism, Genetic IgG Fc receptors Neonatal Fc Receptor (FcRn)
Διαθέσιμο Online:	http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00520/full
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