An overview of mechanisms, biomarkers, and treatment strategies for acquired anti-EGFR resistance in RAS wild-type colorectal cancer

Colorectal cancer (CRC) is a threat to public health, with a global incidence and mortality of over 1.9 million and 0.9 million people, respectively. Anti-epidermal growth factor receptor (EGFR)-based treatment is recommended for CRC with wild-type rat sarcoma (RAS). However, after continuous treatm...

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Principais autores:	Chenxiang Ding, Ruoyu Yao, Yong Wang, Hongjie Liu, Chunyan Li, Hua Xie
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-09-01
Colecção:	Frontiers in Pharmacology
Assuntos:	colorectal cancer acquired anti-EGFR resistance molecular mechanism predictive biomarker coping strategy
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1656372/full
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