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An overview of mechanisms, biomarkers, and treatment strategies for acquired anti-EGFR resistance in RAS wild-type colorectal cancer

Colorectal cancer (CRC) is a threat to public health, with a global incidence and mortality of over 1.9 million and 0.9 million people, respectively. Anti-epidermal growth factor receptor (EGFR)-based treatment is recommended for CRC with wild-type rat sarcoma (RAS). However, after continuous treatm...

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Príomhchruthaitheoirí: Chenxiang Ding, Ruoyu Yao, Yong Wang, Hongjie Liu, Chunyan Li, Hua Xie
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Frontiers Media S.A. 2025-09-01
Sraith:Frontiers in Pharmacology
Ábhair:
Rochtain ar líne:https://www.frontiersin.org/articles/10.3389/fphar.2025.1656372/full
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