Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders

Abstract DNA sensing is a pivotal component of the innate immune system that is responsible for detecting mislocalized DNA and triggering downstream inflammatory pathways. Among the DNA sensors, cyclic GMP-AMP synthase (cGAS) is a primary player in detecting cytosolic DNA, including foreign DNA from...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Yige Huang, Bangyan Liu, Subhash C. Sinha, Sadaf Amin, Li Gan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2023-11-01
coleção:	Molecular Neurodegeneration
Assuntos:	cGAS STING Interferon response Cytosolic dsDNA Antiviral Neuroinflammation
Acesso em linha:	https://doi.org/10.1186/s13024-023-00672-x
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!