Type I Interferon Response Is Mediated by NLRX1-cGAS-STING Signaling in Brain Injury

BackgroundInflammation is a significant contributor to neuronal death and dysfunction following traumatic brain injury (TBI). Recent evidence suggests that interferons may be a key regulator of this response. Our studies evaluated the role of the Cyclic GMP-AMP Synthase-Stimulator of Interferon Gene...

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Hlavní autoři:	Lauren E. Fritsch, Jing Ju, Erwin Kristobal Gudenschwager Basso, Eman Soliman, Swagatika Paul, Jiang Chen, Alexandra M. Kaloss, Elizabeth A. Kowalski, Taylor C. Tuhy, Rachana Deven Somaiya, Xia Wang, Irving Coy Allen, Michelle H. Theus, Alicia M. Pickrell
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2022-02-01
Edice:	Frontiers in Molecular Neuroscience
Témata:	brain injury inflammation STING cGAS innate immunity
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fnmol.2022.852243/full
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