Opportunities and challenges of PROTAC in the treatment of protein-driven diseases
Targeted protein degradation (TPD) has transformed the landscape of drug discovery by exploiting the ubiquitin-proteasome system (UPS) to eliminate, rather than inhibit, pathogenic proteins. This paradigm shift enables access to a vast array of previously “undruggable” targets and offers new therape...
Salvato in:
| Autori principali: | , , , , |
|---|---|
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Elsevier
2026-05-01
|
| Serie: | Results in Chemistry |
| Soggetti: | |
| Accesso online: | http://www.sciencedirect.com/science/article/pii/S2211715626002079 |
| Tags: |
Nessun Tag, puoi essere il primo ad aggiungerne!!
|