An Update on Clinically Advanced PROTAC Degraders and Their Synthesis

Proteolysis-targeting chimeras (PROTACs) have emerged as a revolutionary therapeutic modality that enables degradation of therapeutically relevant proteins through the protein disposal machinery, the ubiquitin-proteasome system (UPS). Unlike traditional small-molecule inhibitors, PROTACs harness bif...

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Bibliografski detalji

Glavni autori:	Ranjan Kumar Acharyya, Yugandhar Kothapalli, Suresh Yarlagadda, Chayan K. De, Srinivasa Rao Allu, Joyeeta Roy, Rohan Kalyan Rej
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2025-12-01
Serija:	Molecules
Teme:	proteolysis-targeting chimeras (PROTACs) target protein degradation (TPD) cancer anti-cancer agents
Online pristup:	https://www.mdpi.com/1420-3049/31/1/33
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