Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (p97-PROTAC)

The p97 protein is a member of the AAA+ family of ATPases. This protein is encoded by the VCP gene. It is a mechanoenzyme that uses energy from ATP hydrolysis to promote protein unfolding and segregation actively. The unfolded products are subsequently presented to the 26S proteasome for degradation...

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Autori principali:	Constanza Salinas-Rebolledo, Javier Blesa, Guillermo Valenzuela-Nieto, David Schwefel, Natalia López-González del Rey, Maxs Méndez-Ruette, Janine Burkhalter, Elizabeth Carrazana, Francisca Díaz-Tejeda, Ignacio Arias Catalán, Claudio Cappelli Leon, Natalia Salvadores, Luis Federico Bátiz, Ronald Jara, José A Obeso, Pedro Chana-Cuevas, Gopal P Sapkota, Alejandro Rojas-Fernandez
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	eLife Sciences Publications Ltd 2025-11-01
Serie:	eLife
Soggetti:	PROTAC nanobody alpaca P97 VCP ubiquitin-free
Accesso online:	https://elifesciences.org/articles/101496
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