QR код

Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (p97-PROTAC)

The p97 protein is a member of the AAA+ family of ATPases. This protein is encoded by the VCP gene. It is a mechanoenzyme that uses energy from ATP hydrolysis to promote protein unfolding and segregation actively. The unfolded products are subsequently presented to the 26S proteasome for degradation...

Повний опис

Збережено в:
Автори: Constanza Salinas-Rebolledo, Javier Blesa, Guillermo Valenzuela-Nieto, David Schwefel, Natalia López-González del Rey, Maxs Méndez-Ruette, Janine Burkhalter, Elizabeth Carrazana, Francisca Díaz-Tejeda, Ignacio Arias Catalán, Claudio Cappelli Leon, Natalia Salvadores, Luis Federico Bátiz, Ronald Jara, José A Obeso, Pedro Chana-Cuevas, Gopal P Sapkota, Alejandro Rojas-Fernandez
Формат: Artigo
Мова:Inglês
Опубліковано: eLife Sciences Publications Ltd 2025-11-01
Серія:eLife
Предмети:
PROTAC
nanobody
alpaca
P97
VCP
ubiquitin-free
Онлайн доступ:https://elifesciences.org/articles/101496
Теги: Додати тег
Немає тегів, Будьте першим, хто поставить тег для цього запису!

Схожі ресурси