Opportunities and challenges of PROTAC in the treatment of protein-driven diseases

Targeted protein degradation (TPD) has transformed the landscape of drug discovery by exploiting the ubiquitin-proteasome system (UPS) to eliminate, rather than inhibit, pathogenic proteins. This paradigm shift enables access to a vast array of previously “undruggable” targets and offers new therape...

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Autors principals:	Zhe Zhou, Peng Liu, Yang Li, Xuelian Liu, Jinyao Li
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2026-05-01
Col·lecció:	Results in Chemistry
Matèries:	Ubiquitin-proteasome system Targeted protein degradation Proteolysis targeting chimera Disease treatment Molecular targets
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2211715626002079
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