Transgenic mice as an alternative to monkeys for neurovirulence testing of live oral poliovirus vaccine: validation by a WHO collaborative study

OBJECTIVE: Extensive WHO collaborative studies were performed to evaluate the suitability of transgenic mice susceptible to poliovirus (TgPVR mice, strain 21, bred and provided by the Central Institute for Experimental Animals, Japan) as an alternative to monkeys in the neurovirulence test (NVT) of...

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Autori principali:	Dragunsky Eugenia, Nomura Tatsuji, Karpinski Kazimir, Furesz John, Wood David J., Pervikov Yuri, Abe Shinobu, Kurata Takeshi, Vanloocke Olivier, Karganova Galina, Taffs Rolf, Heath Alan, Ivshina Anna, Levenbook Inessa
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	The World Health Organization 2003-01-01
Serie:	Bulletin of the World Health Organization
Soggetti:	Poliovirus vaccine, Oral/toxicity Mice, Transgenic/physiology Macaca mulatta Nervous system/virology Virulence Sensitivity and specificity Reproducibility of results World Health Organization Comparative study Validation studies
Accesso online:	http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0042-96862003000400006
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