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CDC42 supports HBV entry by NTCP translocation to the plasma membrane and macropinocytosis

Abstract CDC42 is a member of Rho GTPase family that regulates various biological processes and its activity can be hijacked by invading pathogens. Here, we discovered that the level of active CDC42 in hepatocytes positively correlates with the entry capacity of hepatitis B virus (HBV). Mechanistica...

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Principais autores: Shuzhi Cui, Wei Gao, Yuxin Chen, Yi Xu, Zhifang Li, Yu Wei, Yaming Jiu
Formato: Artigo
Idioma:Inglês
Publicado: Springer Nature 2025-09-01
Series:EMBO Reports
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Acceso en liña:https://doi.org/10.1038/s44319-025-00581-8
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