Hallmark Molecular and Pathological Features of POLG Disease are Recapitulated in Cerebral Organoids

Abstract In this research, a 3D brain organoid model is developed to study POLG‐related encephalopathy, a mitochondrial disease stemming from POLG mutations. Induced pluripotent stem cells (iPSCs) derived from patients with these mutations is utilized to generate cortical organoids, which exhibited...

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Detalhes bibliográficos

Principais autores:	Anbin Chen, Tsering Yangzom, Yu Hong, Bjørn Christian Lundberg, Gareth John Sullivan, Charalampos Tzoulis, Laurence A. Bindoff, Kristina Xiao Liang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2024-05-01
coleção:	Advanced Science
Assuntos:	cortical organoids iPSC mitochondrial function neuron POLG
Acesso em linha:	https://doi.org/10.1002/advs.202307136
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