Hallmark Molecular and Pathological Features of POLG Disease are Recapitulated in Cerebral Organoids
Abstract In this research, a 3D brain organoid model is developed to study POLG‐related encephalopathy, a mitochondrial disease stemming from POLG mutations. Induced pluripotent stem cells (iPSCs) derived from patients with these mutations is utilized to generate cortical organoids, which exhibited...
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| Principais autores: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Wiley
2024-05-01
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| Series: | Advanced Science |
| Assuntos: | |
| Acceso en liña: | https://doi.org/10.1002/advs.202307136 |
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