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Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions

Abstract Macrophages are key immune cells found in atherosclerotic plaques and critically shape atherosclerotic disease development. Targeting the functional repertoire of macrophages may hold novel approaches for future atherosclerosis management. Here, we describe a previously unrecognized role of...

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Principais autores: Marten A Hoeksema, Marion JJ Gijbels, Jan Van den Bossche, Saskia van der Velden, Ayestha Sijm, Annette E Neele, Tom Seijkens, J Lauran Stöger, Svenja Meiler, Marieke CS Boshuizen, Geesje M Dallinga‐Thie, Johannes HM Levels, Louis Boon, Shannon E Mullican, Nathanael J Spann, Jack P Cleutjens, Chris K Glass, Mitchell A Lazar, Carlie JM de Vries, Erik AL Biessen, Mat JAP Daemen, Esther Lutgens, Menno PJ de Winther
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Nature 2014-07-01
coleção:EMBO Molecular Medicine
Assuntos:
atherosclerosis
epigenetics
fibrosis
lipids
macrophages
Acesso em linha:https://doi.org/10.15252/emmm.201404170
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