Epigenetic regulation of cancer progression by EZH2: from biological insights to therapeutic potential
Abstract Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase and a catalytic component of PRC2, catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) to regulate gene expression through epigenetic machinery. EZH2 also functions both as a transcriptional suppressor and a transcript...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BMC
2018-03-01
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| Schriftenreihe: | Biomarker Research |
| Schlagworte: | |
| Online-Zugang: | http://link.springer.com/article/10.1186/s40364-018-0122-2 |
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