Genetic depletion or pharmacological degradation of EZH2 attenuates renal fibrosis via suppressing Notch signaling
Abstract Background Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase that catalyzes the trimethylation of histone H3 at lysine 27 (H3K27me3), has been implicated in promoting renal fibrogenesis. Nevertheless, its precise role and underlying mechanisms remain incompletely defined. Meth...
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| Huvudupphov: | , , , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Utgiven: |
BMC
2025-12-01
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| Serie: | Clinical Epigenetics |
| Ämnen: | |
| Länkar: | https://doi.org/10.1186/s13148-025-02013-9 |
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