Chromium-insulin reduces insulin clearance and enhances insulin signaling by suppressing hepatic insulin-degrading enzyme and proteasome protein expression in KKAy mice

JDS-CRI-003 (CRI) is a novel form of insulin that has been directly conjugated with chromium (Cr) instead of zinc. Our hypothesis was that CRI enhances insulin’s effects by altering insulin degrading enzyme (IDE) and proteasome enzymes. To test this hypothesis, we measured hepatic IDE content and p...

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Principais autores:	Zhong Q Wang, Yongmei eYu, Xian H Zhang, James eKomorowski
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2014-07-01
coleção:	Frontiers in Endocrinology
Assuntos:	Liver insulin signaling Proteasome Chromium-insulin IRS-1 Insulin degrading enzyme
Acesso em linha:	http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00099/full
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