Proteasome Targeting with Carfilzomib Induces Reactive Oxygen Species-Mediated Apoptosis in Hepatoblastoma

Hepatoblastoma (HB) is the most common malignant liver tumor in children, yet therapeutic options remain largely confined to conventional chemotherapy. To identify novel therapeutic targets, we performed gene set enrichment analysis on three publicly available HB datasets and found consistent activa...

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Detalhes bibliográficos

Principais autores:	Elena Johanna Weigl, Salih Demir, Alina Hotes, Emilie Indersie, Sophie Branchereau, Stefano Cairo, Roland Kappler
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2026-05-01
Colecção:	Cells
Assuntos:	hepatoblastoma proteasome inhibition carfilzomib reactive-oxygen-species pathway
Acesso em linha:	https://www.mdpi.com/2073-4409/15/10/864
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