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Proteasome Targeting with Carfilzomib Induces Reactive Oxygen Species-Mediated Apoptosis in Hepatoblastoma

Hepatoblastoma (HB) is the most common malignant liver tumor in children, yet therapeutic options remain largely confined to conventional chemotherapy. To identify novel therapeutic targets, we performed gene set enrichment analysis on three publicly available HB datasets and found consistent activa...

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Principais autores: Elena Johanna Weigl, Salih Demir, Alina Hotes, Emilie Indersie, Sophie Branchereau, Stefano Cairo, Roland Kappler
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-05-01
Serier:Cells
Fag:
hepatoblastoma
proteasome inhibition
carfilzomib
reactive-oxygen-species pathway
Online adgang:https://www.mdpi.com/2073-4409/15/10/864
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