Chromium-insulin reduces insulin clearance and enhances insulin signaling by suppressing hepatic insulin-degrading enzyme and proteasome protein expression in KKAy mice

JDS-CRI-003 (CRI) is a novel form of insulin that has been directly conjugated with chromium (Cr) instead of zinc. Our hypothesis was that CRI enhances insulin’s effects by altering insulin degrading enzyme (IDE) and proteasome enzymes. To test this hypothesis, we measured hepatic IDE content and p...

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Үндсэн зохиолчид:	Zhong Q Wang, Yongmei eYu, Xian H Zhang, James eKomorowski
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Frontiers Media S.A. 2014-07-01
Цуврал:	Frontiers in Endocrinology
Нөхцлүүд:	Liver insulin signaling Proteasome Chromium-insulin IRS-1 Insulin degrading enzyme
Онлайн хандалт:	http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00099/full
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!