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Blocking and binding folate receptor alpha autoantibodies identify novel autism spectrum disorder subgroups

Folate receptor α (FRα) autoantibodies (FRAAs) are prevalent in autism spectrum disorder (ASD). They disrupt the transportation of folate across the blood-brain barrier by binding to the FRα. Children with ASD with FRAAs have been reported to respond well to treatment with a form of folate known as...

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Автори: Richard Eugene Frye, Leanna eDelhey, John eSlattery, Marie eTippett, Rebecca eWynne, Shannon eRose, Stephen Gregory Kahler, Sirish eBennuri, Stepan eMelnyk, Jeffrey M Sequeira, Edward eQuadros
Формат: Artigo
Мова:Inglês
Опубліковано: Frontiers Media S.A. 2016-03-01
Серія:Frontiers in Neuroscience
Предмети:
Glutathione
Autism Spectrum Disorders
folinic acid
Redox metabolism
Folate receptor autoantibody
Онлайн доступ:http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00080/full
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