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Comparison of Three Clinical Trial Treatments for Autism Spectrum Disorder Through Multivariate Analysis of Changes in Metabolic Profiles and Adaptive Behavior

Several studies associate autism spectrum disorder (ASD) pathophysiology with metabolic abnormalities related to DNA methylation and intracellular redox homeostasis. In this regard, three completed clinical trials are reexamined in this work: treatment with (i) methylcobalamin (MeCbl) in combination...

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Principais autores: Troy Vargason, Uwe Kruger, Emily Roth, Leanna M. Delhey, Marie Tippett, Shannon Rose, Sirish C. Bennuri, John C. Slattery, Stepan Melnyk, S. Jill James, Richard E. Frye, Juergen Hahn
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018-12-01
Serier:Frontiers in Cellular Neuroscience
Fag:
autism spectrum disorder
multivariate analysis
one-carbon metabolism
transsulfuration
adaptive behavior
methylcobalamin
Online adgang:https://www.frontiersin.org/article/10.3389/fncel.2018.00503/full
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