Antibacterial activity of a DNA topoisomerase I inhibitor versus fluoroquinolones in Streptococcus pneumoniae.

The DNA topoisomerase complement of Streptococcus pneumoniae is constituted by two type II enzymes (topoisomerase IV and gyrase), and a single type I enzyme (topoisomerase I). These enzymes maintain the DNA topology, which is essential for replication and transcription. While fluoroquinolones target...

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主要な著者:	Myriam V Valenzuela, Mirian Domenech, Patricia Mateos-Martínez, Fernando González-Camacho, Adela G de la Campa, Maria Teresa García
フォーマット:	Artigo
言語:	Inglês
出版事項:	Public Library of Science (PLoS) 2020-01-01
シリーズ:	PLoS ONE
オンライン･アクセス:	https://doi.org/10.1371/journal.pone.0241780
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