Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro.

The MICs of trovafloxacin, ciprofloxacin, ofloxacin, and sparfloxacin at which 90% of isolates are inhibited for 55 isolates of pneumococci were 0.125, 1, 4, and 0.5 microgram/ml, respectively. Resistant mutants of two susceptible isolates were selected in a stepwise fashion on agar containing cipro...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Gootz, T D, Zaniewski, R, Haskell, S, Schmieder, B, Tankovic, J, Girard, D, Courvalin, P, Polzer, R J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163605/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9124824/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.12.2691
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