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Genomics and epigenetics guided identification of tissue-specific genomic safe harbors

Abstract Background Genomic safe harbors are regions of the genome that can maintain transgene expression without disrupting the function of host cells. Genomic safe harbors play an increasingly important role in improving the efficiency and safety of genome engineering. However, limited safe harbor...

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Principais autores: Dewan Shrestha, Aishee Bag, Ruiqiong Wu, Yeting Zhang, Xing Tang, Qian Qi, Jinchuan Xing, Yong Cheng
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-09-01
coleção:Genome Biology
Assuntos:
Genomic safe harbor
Genetic engineering
Gene therapy
Epigenome
Chromatin organization
Mobile genetic elements
Acesso em linha:https://doi.org/10.1186/s13059-022-02770-3
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