Human Genome Safe Harbor Sites: A Comprehensive Review of Criteria, Discovery, Features, and Applications

The stable and safe integration of exogenous DNA into the genome is crucial to both genetic engineering and gene therapy. Traditional transgenesis approaches, such as those using retroviral vectors, result in random genomic integration, posing the risk of insertional mutagenesis and transcriptional...

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Detalhes bibliográficos

Principais autores:	Amer Ahmed, Daria Di Molfetta, Giorgia Natalia Iaconisi, Antonello Caponio, Ansu Singh, Aasia Bibi, Vincenza Dolce, Luigi Palmieri, Vincenzo Coppola, Giuseppe Fiermonte
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2026-01-01
coleção:	Cells
Assuntos:	safe harbor sites genome transgenes gene therapy CRISPR/CAS9 AAVS1
Acesso em linha:	https://www.mdpi.com/2073-4409/15/1/81
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