High content-imaging drug synergy screening identifies specific senescence-related vulnerabilities of mesenchymal neuroblastomas

Abstract Neuroblastomas encompass malignant cells with varying degrees of differentiation, ranging from adrenergic (adr) cells resembling the sympathoadrenal lineage to undifferentiated, stem-cell-like mesenchymal (mes) cancer cells. Relapsed neuroblastomas, which often have mesenchymal features, ha...

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Bibliografische Detailangaben

Hauptverfasser:	Sonja Herter, Marta Emperador, Kyriaki Smyrilli, Daniela Kocher, Simay Celikyürekli, Constantia Zeiser, Xenia Gerloff, Sina Kreth, Kai-Oliver Henrich, Kendra K. Maaß, Johanna Rettenmeier, Thomas G. P. Grünewald, Heike Peterziel, Frank Westermann, Anne Hamacher-Brady, Olaf Witt, Ina Oehme
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2025-08-01
Schriftenreihe:	Cell Death and Disease
Online-Zugang:	https://doi.org/10.1038/s41419-025-07933-1
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