High content-imaging drug synergy screening identifies specific senescence-related vulnerabilities of mesenchymal neuroblastomas

Abstract Neuroblastomas encompass malignant cells with varying degrees of differentiation, ranging from adrenergic (adr) cells resembling the sympathoadrenal lineage to undifferentiated, stem-cell-like mesenchymal (mes) cancer cells. Relapsed neuroblastomas, which often have mesenchymal features, ha...

Descrizione completa

Dettagli Bibliografici

Autori principali:	Sonja Herter, Marta Emperador, Kyriaki Smyrilli, Daniela Kocher, Simay Celikyürekli, Constantia Zeiser, Xenia Gerloff, Sina Kreth, Kai-Oliver Henrich, Kendra K. Maaß, Johanna Rettenmeier, Thomas G. P. Grünewald, Heike Peterziel, Frank Westermann, Anne Hamacher-Brady, Olaf Witt, Ina Oehme
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2025-08-01
Serie:	Cell Death and Disease
Accesso online:	https://doi.org/10.1038/s41419-025-07933-1
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!