Prolonged exposure to teixobactin generates cross-tolerance to other cell wall-targeting antimicrobials in Enterococcus faecalis

ABSTRACT Antimicrobial tolerance, i.e., the ability to survive despite growth inhibition, is an important precursor to the development of antimicrobial resistance. However, very little is known about the evolution of drug-induced antimicrobial tolerance. Teixobactin (TXB) is an antimicrobial peptide...

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Principais autores:	Rachel L. Darnell, Melanie K. Knottenbelt, Olivia E. Rose, Caitlin S. B. Cleary, Francesca O. Todd Rose, Hannah Hodgkinson, Yuezhou Wu, Maytham Hussein, Tony Velkov, Susanne Gebhard, Gregory M. Cook
Formato:	Artigo
Idioma:	Inglês
Publicado:	ASM 2025-12-01
Series:	Antimicrobial Agents and Chemotherapy
Assuntos:	mevalonate pathway cell envelope stress response LiaFSR cross-tolerance Enterococcus cell wall targeting
Acceso en liña:	https://journals.asm.org/doi/10.1128/aac.00629-25
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