Prolonged exposure to teixobactin generates cross-tolerance to other cell wall-targeting antimicrobials in Enterococcus faecalis

ABSTRACT Antimicrobial tolerance, i.e., the ability to survive despite growth inhibition, is an important precursor to the development of antimicrobial resistance. However, very little is known about the evolution of drug-induced antimicrobial tolerance. Teixobactin (TXB) is an antimicrobial peptide...

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Bibliografische Detailangaben

Hauptverfasser:	Rachel L. Darnell, Melanie K. Knottenbelt, Olivia E. Rose, Caitlin S. B. Cleary, Francesca O. Todd Rose, Hannah Hodgkinson, Yuezhou Wu, Maytham Hussein, Tony Velkov, Susanne Gebhard, Gregory M. Cook
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	ASM 2025-12-01
Schriftenreihe:	Antimicrobial Agents and Chemotherapy
Schlagworte:	mevalonate pathway cell envelope stress response LiaFSR cross-tolerance Enterococcus cell wall targeting
Online-Zugang:	https://journals.asm.org/doi/10.1128/aac.00629-25
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