Paeoniflorin Ameliorates Skeletal Muscle Atrophy in Chronic Kidney Disease via AMPK/SIRT1/PGC-1α-Mediated Oxidative Stress and Mitochondrial Dysfunction

Skeletal muscle atrophy is a common and serious complication of chronic kidney disease (CKD). Oxidative stress and mitochondrial dysfunction are involved in the pathogenesis of muscle atrophy. The aim of this study was to explore the effects and mechanisms of paeoniflorin on CKD skeletal muscle atro...

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Hlavní autoři:	Qiang Li, Jing Wu, Jiawen Huang, Rong Hu, Haiyan You, Lingyu Liu, Dongtao Wang, Lianbo Wei
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2022-03-01
Edice:	Frontiers in Pharmacology
Témata:	paeoniflorin chronic kidney disease skeletal muscle atrophy oxidative stress mitochondrial dysfunction AMPK/SIRT1/PGC-1α
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fphar.2022.859723/full
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