Sodium butyrate improves renal injury in diabetic nephropathy through AMPK/SIRT1/PGC-1α signaling pathway

Abstract Diabetic nephropathy (DN) is a prototypical chronic energy metabolism imbalance disease. The AMPK/Sirt1/PGC-1α signaling pathway plays a pivotal role in regulating energy metabolism throughout the body. Gut microbiota ferment indigestible carbohydrates to produce a variety of metabolites, p...

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Hlavní autoři:	Kaili Ye, Yanling Zhao, Wen Huang, Yonglin Zhu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2024-08-01
Edice:	Scientific Reports
Témata:	Diabetic nephropathy Short-chain fatty acids Sodium butyrate Gut microbiota AMPK/Sirt1/PGC-1α signaling pathway
On-line přístup:	https://doi.org/10.1038/s41598-024-68227-8
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