SLC20A1 knockout to stably express a fusogenic gibbon ape leukemia virus envelope glycoprotein for lentiviral vector production

Lentiviral vectors (LVs) derived from HIV-1 are widely used in gene therapy, with several approved products. However, establishing stable cell lines for constitutive LV production remains a challenge due to the cytotoxicity of vector proteins, including some envelope glycoproteins used for pseudotyp...

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Autors principals:	Rodrigo José Nogueira, Ana Filipa Rodrigues, Daniel Alexandre Mestre, Ana Sofia Coroadinha
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2025-12-01
Col·lecció:	Molecular Therapy: Methods & Clinical Development
Matèries:	lentiviral vectors stable cell lines constitutive lentiviral vector production fusogenic envelope glycoprotein syncytia receptor knockout
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2329050125002141
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